Important Safety Information Medication Guide and Prescribing Information
Logo go to home page
Previous
Next

Personalized Dosing

Personalized dosing in a long-acting liquid1

Liquid Quillivant XR (methylphenidate HCI) allows your doctor to adjust the dose, up or down, weekly, in amounts of 2 to 4 mL.1

Liquid dosing starting at 20 mg to help balance side effects and efficacy.

  • Your healthcare provider will identify your child's dose by adjusting it up or down in small amounts based on your child's response to treatment
  • Quillivant XR should be taken by mouth once daily in the morning
  • Quillivant XR can be taken with or without food
  • Quillivant XR comes with an oral dosing dispenser to help you measure the correct amount of medication
  • Take Quillivant XR exactly as prescribed and remember that you MUST shake the bottle vigorously for at least 10 seconds prior to each use
Find out answers to FAQs about Quillivant XR dosing

Did you know...?

Quillivant XR was shown to begin working from 45 minutes after taking it.
From 45 Minutes Rapid Onset of Effect Icon

How to take Quillivant XR

Read the Instructions for Use for Quillivant XR you received from your pharmacist before taking Quillivant XR and every time you get a refill so that you have the most up-to-date instructions.

If you have any questions, talk to your healthcare provider about your or your child’s medical condition or treatment.

How to Take Quillivant XR Methylphenidate Step 1 (Figure A): Box, Oral Dosing Dispenser, & Bottle

Figure A

Step 1

  • Remove the Quillivant XR bottle and oral dosing dispenser from the box (See Figure A). If the oral dosing dispenser is missing or not provided, please contact your pharmacist for a replacement.
How to Take Quillivant XR Methylphenidate Step 2 (Figure B): Bottle with Liquid

Figure B

Step 2

  • Check and make sure that the Quillivant XR bottle contains liquid medicine (See Figure B). If Quillivant XR is still in powder form, do not use it. Return it to your pharmacist.
How to Take Quillivant XR Methylphenidate Step 3 (Figure C): Shake Bottle with Liquid Well

Figure C

Step 3

  • Shake the bottle well (up and down) for at least 10 seconds before each use (See Figure C).
How to Take Quillivant XR Methylphenidate Step 4 (Figure D): Twist Cap Off Bottle Adapter

Figure D

How to Take Quillivant XR Methylphenidate Step 4 Continued (Figure E & F): Press Bottle Adapter Down

Figure E / Figure F

How to Take Quillivant XR Methylphenidate Step 4 Continued (Figure G): Bottle Adapter Fully Inserted

Figure G

Step 4

  • Uncap the bottle and check that the bottle adapter has been fully inserted into the bottle (See Figure D).

Step 4 (continued)

  • If bottle adapter (See Figure E) has not been inserted by the pharmacist into the bottle, insert adapter into the bottle as shown (See Figure E and Figure F).
  • After the bottle adapter has been fully inserted into the bottle (See Figure G), it should not be removed. If the bottle adapter has not been inserted and is missing from the box, contact your pharmacist.
  • The bottle adapter must be fully inserted and should be even with the mouth of the bottle and must remain in place to allow the child resistant cap to work the right way.
How to Take Quillivant XR Methylphenidate Step 5 (Figure H): Dosing Plunger

Figure H

Step 5

  • Check the Quillivant XR dose in milliliters (mL) as prescribed by your health care provider. Locate this number on the oral dosing dispenser (See Figure H).
How to Take Quillivant XR Methylphenidate Step 6 (Figure I): Insert Dosing Plunger Into Bottle Adapter

Figure I

Step 6

  • Insert tip of the oral dosing dispenser into the upright bottle and push the plunger all the way down (See Figure I).
How to Take Quillivant XR Methylphenidate Step 7 (Figure J): Pull Dosing Plunger Down

Figure J

How to Take Quillivant XR Methylphenidate Step 7 Continued (Figure K): Measure with Dosing Plunger

Figure K

Step 7

  • With the oral dosing dispenser in place, turn the bottle upside down. Pull the plunger to the number of mL you need (the amount of liquid medicine in Step 5 – See Figure J).

Step 7 (continued)

  • Measure the number of mL of medicine from the white end of the plunger (See Figure K).
How to Take Quillivant XR Methylphenidate Step 8 & 9 (Figure L): Adminster Liquid Into Mouth Using Dosing Plunger

Figure L

Step 8

  • Remove the oral dosing dispenser from the bottle adapter.

Step 9

  • Slowly squirt Quillivant XR directly into your or your child’s mouth (See Figure L).
How to Take Quillivant XR Methylphenidate Step 10 (Figure M): Twist Cap Back Onto Bottle Adapter

Figure M

Step 10

  • Cap the bottle tightly. Store the bottle upright at 59°F to 86°F (15°C to 30°C) (See Figure M)
How to Take Quillivant XR Methylphenidate Step 11 (Figure N): Wash Dosing Plunger

Figure N

Step 11

  • Clean the oral dosing dispenser after each use by placing in the dishwasher, or by rinsing with tap water (See Figure N).

Keep Quillivant XR and all medicines out of the reach of children.

Learn about the steady medication release of Quillivant XR

References: 1. Quillivant XR [package insert]. Tris Pharma, Inc., Monmouth Junction, NJ.

Important Safety Information

Quillivant® XR (methylphenidate HCI) is a federally controlled substance (CII) because it contains methylphenidate that can be a target for people who abuse prescription medicines or street drugs. Quillivant XR has a high chance for abuse and misuse and may lead to substance use problems, including addiction. Keep Quillivant XR in a safe place to prevent abuse and misuse. Never give your Quillivant XR to anyone else, because it may cause death or harm them. Selling or giving away Quillivant XR may harm others and is against the law.

See Additional Important Safety Information.
To report SUSPECTED ADVERSE REACTIONS, contact Tris Pharma, Inc. at (732) 940-0358 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

Important Safety Information

Quillivant® XR (methylphenidate HCI) is a federally controlled substance (CII) because it contains methylphenidate that can be a target for people who abuse prescription medicines or street drugs. Quillivant XR has a high chance for abuse and misuse and may lead to substance use problems, including addiction. Keep Quillivant XR in a safe place to prevent abuse and misuse. Never give your Quillivant XR to anyone else, because it may cause death or harm them. Selling or giving away Quillivant XR may harm others and is against the law.

Your healthcare provider should check you or your child’s risk for abuse, misuse, and addiction before starting treatment with Quillivant XR and will monitor you or your child during treatment. Tell your physician if you, your child, or any family members have ever abused or been dependent on alcohol, prescription medicines, or street drugs.

Quillivant XR should not be taken if you or your child are allergic to methylphenidate hydrochloride, or any of the ingredients in Quillivant XR, or are taking or have taken within the past 14 days an antidepression medicine called a monoamine oxidase inhibitor or MAOI.

The following have been reported with the use of methylphenidate hydrochloride and other stimulant medicines:

  • Risks for people with serious heart disease: Sudden death has happened in people who have heart defects or other serious heart disease. Before starting Quillivant XR, tell your healthcare provider if you or your child have any heart problems, heart disease, or heart defects.
    Call your healthcare provider or go to the nearest hospital emergency room right away if you or your child has any signs of heart problems such as chest pain, shortness of breath, or fainting during treatment with Quillivant XR.
  • Increase in blood pressure and heart rate.
    Your healthcare provider should check your or your child’s blood pressure and heart rate regularly during treatment with Quillivant XR.
  • Mental (psychiatric) problems, including new or worse behavior and thought problems, new or worse bipolar illness, new psychotic symptoms (such as hearing voices, or seeing or believing things that are not real) or new manic symptoms. Tell your healthcare provider about any mental problems you or your child have, or about a family history of suicide, bipolar illness, or depression. Call the doctor right away if there are any new or worsening mental symptoms during treatment.

Quillivant XR may not be right for you or your child. Before starting Quillivant XR tell your or your child’s health care provider about all health conditions (or a family history of) including:

  • heart problems, heart disease, heart defects, or high blood pressure
  • mental problems including psychosis, mania, bipolar illness, or depression
  • circulation problems in fingers and toes
  • have eye problems, including increased pressure in your eye, glaucoma, or problems with your close-up vision (farsightedness)
  • have or had repeated movements or sounds (tics) or Tourette’s syndrome, or have a family history of tics or Tourette’s syndrome
  • if you are pregnant or plan to become pregnant. It is not known if Quillivant XR will harm the unborn baby. There is a pregnancy registry for females who are exposed to Quillivant XR during pregnancy. The purpose of the registry is to collect information about the health of females exposed to Quillivant XR and their baby. If you or your child becomes pregnant during treatment with Quillivant XR, talk to your healthcare provider about registering with the National Pregnancy Registry for Psychostimulants at 1-866-961-2388 or https://womensmentalhealth.org/clinical-and-research-programs/pregnancyregistry/othermedications/.
  • if you are breastfeeding or plan to breast feed. Quillivant XR passes into your breast milk. You and your healthcare provider should decide if you will take Quillivant XR or breastfeed.
  • Do not start any new medicine while taking Quillivant XR without talking to your healthcare provider first.

What should I avoid while taking Quillivant XR?

Quillivant XR should not be taken with MAOI medicines or if you stopped taking an MAOI in the last 14 days. Do not drink alcohol while taking Quillivant XR. This may cause a faster release of your methylphenidate dose.

Quillivant XR may cause serious side eff­ects, including:

  • See “What is the most important information I should know about Quillivant XR?” for information on reported heart and mental problems

Other serious side eff­ects include:

  • Circulation problems in fingers and toes (peripheral vasculopathy, including Raynaud’s phenomenon). Tell your healthcare provider if you or your child have numbness, pain, skin color change, or sensitivity to temperature in your fingers or toes.
    Call the doctor right away if you or your child have any signs of unexplained wounds appearing on fingers or toes during treatment with Quillivant XR.
  • New or worsening tics or worsening Tourette’s syndrome. Tell your healthcare provider if you or your child get any new or worsening tics or worsening Tourette’s syndrome during treatment with Quillivant XR.
  • Painful and prolonged erections (priapism) have occurred with methylphenidate. If you or your child develop priapism seek medical help right away. Because priapism can cause long lasting damage, it should be checked by a health care provider right away.
  • Slowing of growth (height and weight) in children. Children should have their height and weight checked often during treatment with Quillivant XR. Quillivant XR treatment may be stopped if your child is not gaining weight or height.
  • Eye problems (increased pressure in the eye and glaucoma). Call your healthcare provider right away if you or your child develop changes in your vision or eye pain, swelling, or redness.

Most Common side eff­ects include:

  • Decreased appetite
  • Trouble sleeping
  • Nausea
  • Vomiting
  • Indigestion
  • Stomach pain
  • Weight loss
  • Anxiety
  • Dizziness
  • Irritability
  • Mood swings
  • Fast heart beat
  • Increased blood pressure

These are not all the possible side effects of Quillivant XR.

To report SUSPECTED ADVERSE REACTIONS, contact Tris Pharma, Inc. at (732) 940-0358 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is Quillivant XR?

Quillivant XR is a central nervous system stimulant prescription medicines. Quillivant XR is a chewable tablet.

Quillivant XR is used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). Quillivant XR may help increase attention and decrease impulsiveness and hyperactivity in people with ADHD.

It is not known if Quillivant XR is safe and effective in children under 6 years of age.

Please see Full Prescribing Information for Quillivant XR, including Boxed Warning about Abuse, Misuse and Addiction, and Medication Guide.

up arrowTop